Modern medicine primarily depends on a wide range of drugs to fight against numerous chronic diseases such as tuberculosis, malaria, pneumonia, and HIV-AIDS. One of the most deadly diseases present in the world is cancer which is yet to be cured completely. The only way to reduce its impact and curb the disease is through chemotherapy. Chemotherapy agents are known to have prolonged lives for cancer patients. They can cure the disease; however, it also led to the condition turning into a chronic one. Even then, the biggest hurdle with the approach for modern pharmacology and medicine is to get the drugs into the disease-ridden cells.
A research team undertook the task of tackling this problem and has found a practical solution. The new approach would be a groundbreaking development for the cancer treatment sector and the Carbon Nanotube (CNT) Market as it provides that the use of carbon nanotubes could potentially enable direct drug delivery from liposomes into the cell interior. This could be done by facilitating the fusion of the carrier membrane and the cell. This new research is extremely beneficial as it might help patients get cured more effectively.
Conventionally produced drugs are usually poorly soluble, intensely toxic against other tissues, or undergo rapid degradation in different chemical environments within an organism. In addition, drugs pose problems as they can accumulate in non-target issues or bind themselves to other cellular components. Further, they at times may also not internalize efficiently into the targeted cells. Thus, researchers came with the idea of using carbon nanotube porins. They are short pieces of carbon nanotubes embedded into lipid membranes. Their work is to mimic viral fusion peptide functionality to enable the fusion of liposomal carriers to the membranes of cancer cells.
This research can open new gates for effective and practical drug delivery carriers, which can be useful for a wide range of therapeutics. In addition, the team was able to successfully demonstrate the fusion through small diameter carbon nanotube porins as it can help mix the membrane material with vesicle interior content.
The experiment revealed that CNTP-studded liposomes could facilitate the construction of the much-awaited but so far elusive, versatile carrier. That can be used for direct and highly efficient delivery of drugs and RNA and DNA vaccines throughout the plasma membrane. Furthermore, this strategy is impressive enough to bypass the endocytotic pathway altogether, avoiding some critical problems encountered with the previous delivery strategies.
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