Vitamin B3 - Niacin Intake Assists in Fighting Neuromuscular Disorder, Cancer

  • Analysis
  • 20-November-2020

Niacin is a form of vitamin B3, an organic compound that is a vital human nutrient. It is also known as nicotinic acid.  It occurs naturally in many foods such as meat, greens, poultry, eggs, and fish. Many food products are fortified with niacin at some stage in manufacturing. Niacin is a significant nutrient in both food and supplements. There are also two main forms of vitamin B3 nicotinic acid and nicotinamide (NAM). Scientists revealed that it could be considered a promising treatment option for muscle disease and reduce non-melanoma skin cancers. Some of the recent research studies show the high potential of vitamin B3 (niacin) in treating various health issues, thus gaining attention from pharma firms across the world to explore Vitamin B3 market.
Vitamin B3 rejuvenates energy metabolism in muscle disease.

A scientist team led by the University of Helsinki has found that vitamin B3 or niacin can delay disease development in patients with mitochondrial myopathy. It is a progressive disease with no earlier therapeutic treatments. The disease is characterized by progressive muscle weakness, cramps, and exercise intolerance. At present, there are no treatments exist that would decelerate disease progression.

The research study found that patients with Mitochondrial myopathy have a deficiency of NAD+ in muscle and blood.  Niacin acts as an efficient NAD+ booster in humans. The Niacin treatment competently augmented blood NAD+ in both inpatients and healthy subjects. Niacin restored NAD+ in the patients' muscle to the normal level and enhanced strength of large muscles and mitochondrial oxidative capacity.

Moreover, Niacin improves muscle strength together with fatty liver in mitochondrial myopathy. It enhances respiratory chain activity and muscle mitochondrial biogenesis y in humans.

The study revealed that niacin is an optimistic treatment choice for mitochondrial myopathy. However, niacin and NAD+ are proficient metabolic modifiers, and niacin treatment should be carefully applied only when NAD deficiency is detected in the patient’s blood.
Niacin helps in repairing potentially cancerous skin damage.

Non-melanoma skin cancers are one of the most widespread tumors amongst white patients. The chief risk factor for these growths is excess exposure to the radiation of the Sun. These rays also harm the DNA, cause inflammation, diminish cellular energy, and kill cells.

A team of Researchers study in Italy finds niacin (vitamin B3) a better option to protect the skin from ultraviolet (UV) exposure and lower the risk of developing skin cancer. By raising Vitamin, B3 consumption has the potential to protect the skin from some of the impacts of UV exposure, minimizing the incidence of non-melanoma skin cancers.
The Italian team studied cells from the skin of patients detected with non-melanoma skin cancers. Researchers treated these cancers with three different NAM doses for 48, 24, and 18 hours. The samples were then brought to Ultraviolet light.

The study results disclose that pre-treating cells with this form of niacin a day earlier than exposure to UV radiation can protect them from oxidative stress. This also includes DNA damage caused by ultraviolet rays. NAM also helped to augment DNA repair in these cells by declining the expression of the enzyme OGG1. Furthur, niacin reduces antioxidant expression and prohibited local inflammation by decreasing nitric oxides (NO) and reactive oxygen species (ROS) production.

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