At present, sedative drugs which are often used in the medication consist of phenobarbitone, secobarbital, pentobarbital, and amobarbital. All these drugs have a beneficial effect only if used under medical supervision.
One of the first sedatives to be discovered and widely used was phenobarbital. In the early 20th century it was commonly used as a general anesthetic, to keep patients unconscious during surgery. Phenobarbital is an example of a barbiturate. Up till now in today’s date Barbiturates are sometimes used for general anesthetic during surgeries and occasionally by people with epilepsy when milder drugs fail to control seizures.
It entails a variety of drugs with a different mode of action that can induce depression of the central nervous system (CNS). In the early days, the pharmacotherapy of insomnia and anxiety depend on barbiturates, later which were then replaced with benzodiazepines as drugs of choice. Besides those two groups of drugs, other sedatives are also used for that purpose.
Apart from their advantages, sedatives can have an adverse effect on the body if misused or accidentally combined, as in the case of combining prescription sedatives with alcohol, they can dangerously depress important signals that are needed to maintain heart and lung function. Most sedatives also have addictive potential. For these reasons, sedatives should be used under supervision and only as necessary.
Sedatives are generally classified according to the way they affect the human body. They represent a group of drugs that share an ability to reduce the activity of CNS and diminish the brain’s level of awareness. The lack of similarity between the structures of drugs that belong to different classes made it difficult to propose a common receptor or mechanism of action.
Basically, the market of sedatives is growing on the ground of growing geriatric population base, rising adoption of a sedentary lifestyle, increasing number of surgeries, rising spending’s on healthcare.
Also, sedatives drugs are used in density as an anesthesia as it offers the pain-free and anxiety-free procedure. In addition to this, it also provides an opportunity to perform multiple or lengthy dental procedures in one session, minimizing the number of visits a patient has to make and ultimately reducing the buildup of anxiety prior to each dental visit. Thus, the market for sedatives is building up owing their increasing application in dentistry.
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