Progression of Heart failure is one of the biggest causes of death in the world. Two factors that drive this problem are fibrosis and inflammation. After a heart attack, an inflammatory response is triggered that sets off several biological events, leading to structural changes in the heart, thus, resulting in the organ’s ability to pump blood. Through a process known as cardiac remodeling, scientists have thought of ways to find a drug that would be able to interrupt this process. However, as there is a shortage of information on how the process actually unfolds, their efforts have not been fruitful yet.
A group of researchers has started up a study to research the biological processes due to which people suffer from inflammation after heart attacks. This may empower us to find therapies that would help patients recover more thoroughly while also reducing the risk of permanent heart damage. This new study may be a considerable development in Congenital Heart Disease Industry, and such therapies to help heart patients are much needed for a long time. They would help them live their lives to their best while having fewer side effects of having a heart attack.
Whenever any patient with heart attack symptoms arrives in an emergency room, doctors focus on recovering the blood flow to the heart muscle towards its average rate. As decades have passed, therapeutic techniques used to get the blood flowing and reduce the heart's strain have significantly advanced. Hence, the chances of patients surviving heart attack events have improved from earlier 50% to more than 90% today. However, there is still so much needs to be done to better these statistics. This is because survivors face the risk of suffering from future heart failures or attacks, and current therapies are inefficient in curbing these future risks.
The situation of heart patients is quite delicate as even a brief cut of blood supply can lead to an inflammatory response, in turn weakening the heart and leaving it with lasting scars. In positron emission tomography (PET) scans, inflammatory cells are visible in colored areas, wherein brighter colored areas refer to denser cell clusters. If there is a bright spot on the heart, it means that cells are present together in a part that has lost the blood supply, resulting in a heart attack.
Researchers are aware that the problem lies with the process of inflammation; however, the immune system is an intricate subject. So, there may be several ways to ensure detrimental cardiac remodeling, and various types of patients may benefit from different therapies. Thus, researchers need to ensure that treatments can target immune cells and deliver such therapies to patients who would benefit from them.
As there is an urgent need to understand the process of how everything works, researchers need visual information of what actually goes on inside the heart after an individual suffers from a heart attack. Some patients recover reasonably well after a heart attack, while some don’t. Some have to go through several side effects after their recovery, and there is no material present that explains the reasons why.
The team has undertaken this study to combine the data present from imaging the inside of the heart to reach such therapies that will help patients recover from a heart attack so that their health gets better more thoroughly without any side effects.
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