Bipolar disease produces dramatic mood fluctuations ranging from mania to depression. At the same time, schizophrenia is a severe, long-term mental health condition that can include hallucinations, delusions, and disturbed thinking and behavior. The symptoms can make it difficult to distinguish between the two illnesses. Both disorders are severe mental illnesses that are difficult to identify and cure. Despite being one of the most inherited mental health illnesses, relatively few clues to its cause have been discovered in the genes that make up our DNA.
As per a Cambridge-led team, proteins are created by approximately 248,000 sections of the dark genome and are disrupted in various disorders. They've now uncovered novel proteins that arise from recently evolved areas of the 'black genome,' the findings could help huge advantage for Schizophrenia Treatments Market as it would be possible to diagnose and treat schizophrenia and bipolar illness.
Researchers have been studying the 'dark genome' of DNA outside of genes for a long time. They recently uncovered evolved sections that code schizophrenia and bipolar disorder proteins.
They claim that these new proteins can be used as biological markers to discriminate between the two illnesses. Further, they could help identify people more likely to suffer from psychosis or commit suicide.
The team also discovered sections of the genome that produce proteins that appear to be linked to schizophrenia and bipolar illness. This was done by scanning the complete genome. Even though these regions are not classified as genes in the traditional sense, they were still critical for the present study. The findings open the door to a plethora of new druggable targets. It's particularly fascinating because no one has ever looked for hints to understanding and treating these diseases outside of the genes previously.
The traditional concept of a gene is relatively narrow, and it has led scientists away from studying the remainder of the genome's function. Researchers discovered novel proteins that play an essential role in biological processes. They believe their malfunction leads to mental illnesses such as schizophrenia and bipolar disorder.
The researchers also uncovered that hotspots in the 'dark genome' got linked to the disorders. This occurred because they serve a useful purpose in human development, but that their disruption by environmental factors causes vulnerability to or development of schizophrenia or bipolar disorder.
The majority of currently available medications are aimed at genes that code for proteins. The discovery explains why schizophrenia and bipolar illness are heritable disorders and could lead to novel therapeutic targets in the future.
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