Big Advancement in CRISPR Market: Newly Developed CRISPR 3.0 Can Boost Multi Genes Function Simultaneously

• Analysis
• 12-July-2021

Editing refers to generating a loss of function to improve the yield. Several systems have been built for simultaneous gene editing (multiplexed editing). However, the strategy is finite in nature as genes are exhaustive; thus, the process of engineering and breeding better traits is very limited. In addition, it can also be so that plants have already evolved to comprise of different pathways, traits, and defense mechanisms, and all they require is a little boost.

Now researchers have introduced a new and better CRISPR 3.0 system for plants that focuses on gene activation rather than conventional gene editing. The third generation CRISPR system is a great advancement for CRISPR Market as it has the ability to mainly focus on multiplexed gene activation, thus resulting in a boost of multi genes’ function simultaneously.

Researchers stated that their innovative system contains four to six times better activation capacity in contrast to the present state-of-the-art CRISPR technology. They give evidence of high accuracy and efficacy in up to seven genes at one time. CRISPR technologies with gene editing capacities can eliminate genes that are undesirable; however, genes to achieve functionality are critical for creating better plants and crops for the future.

The team evaluated CRISPR 3.0 systems in Arabidopsis (the widely known model plant species, also known as rockcress), rice, and tomatoes. They proved that one could simultaneously activate several types of genes, in addition to faster flowering to enhance the speed of the breeding process.

 Generally, CRISPR is thought akin to “molecular scissors” that can cut DNA, and so the present activation system also used deactivated CRISPR-Cas9 that can only bind. As it does not have the ability to cut, the system only focuses on recruiting activation proteins for genes of particular interest by binding them to certain segments of DNA instead. Furthermore, the team tested the SpRY variant of CRISPR-Cas9 that expands the potential of stuff that can be targeted for activation and deactivation from the former CRISPR-Cas12b system proving versatility across all CRISPR systems.

Now, there is a more streamlined process for multiplexed activation, which might lead to significant breakthroughs in the future. For instance, this technology can be made use for screening the genome more effectively and efficiently for genes having the ability to fight important causes like global hunger and climate change. Further, the new system can empower to design, tailor and track gene activation at a larger scale so that genes of importance can be screened. All these prospects collectively might enable researchers to advance ahead in discovery and translational science within plants.

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